Potassium Carbonate → 6-bromo-N-(2-(diethylamino)ethyl)phthalazin-1-amine

HRID 2357605ノート

反応式

HRID 2357605 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][N:6]=[CH:5]2.C(=O)([O-])[O-].[K+].[K+].[CH2:19]([N:21]([CH2:25][CH3:26])[CH2:22][CH2:23][NH2:24])[CH3:20]>CN(C)C=O.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([NH:24][CH2:23][CH2:22][N:21]([CH2:25][CH3:26])[CH2:19][CH3:20])=[N:7][N:6]=[CH:5]2

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 60993N,N-DiethylethylenediamineHCID 220304246-Bromo-1-chlorophthalazine

生成物 1

HCID 684546736-bromo-N-(2-(diethylamino)ethyl)phthalazin-1-amine

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

6-Bromo-1-chlorophthalazine (0.22 g, 0.91 mmol) was dissolved in N,N-dimethylformamide (3 mL) and potassium carbonate (0.25 g, 1.81 mmol) and N1,N1-diethylethane-1,2-diamine (0.25 mL, 1.81 mmol) were added. The reaction mixture was heated to 80° C. for 5 h, cooled to ambient temperature and stirred for 16 h. The reaction mixture was diluted with 20 mL of EtOAc, added to an addition funnel and partitioned with sodium bicarbonate (saturated, aqueous). The organic layer was washed 3× with 20 mL of sodium bicarbonate (saturated, aqueous) and once with aqueous brine, separated, dried over sodium sulfate, and concentrated via rotovap to give crude product. The crude was purified by chromatography to obtain the title compound. Found MS (ES+): 323(M+H)+.

後処理

  1. temperaturecooled to ambient temperature
  2. additionadded to an addition funnel
  3. custompartitioned with sodium bicarbonate (saturated, aqueous)
  4. washThe organic layer was washed 3× with 20 mL of sodium bicarbonate (saturated, aqueous)
  5. customonce with aqueous brine, separated
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated via rotovap
  8. customto give crude product
  9. customThe crude was purified by chromatography

出典と根拠

ORDレコード
ord-716d62a92dbf4913a5d22346c3782f3a
出典データセット
uspto-grants-2010_07
特許番号
US07759337B2

反応ノート

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