Dimethylamine → 5-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine

HRID 2357659ノート

反応式

HRID 2357659 の反応式
[CH3:1][NH:2][CH3:3].[Br:4][C:5]1[C:6]([O:12][CH3:13])=[N:7][C:8](Cl)=[N:9][CH:10]=1>>[Br:4][C:5]1[C:6]([O:12][CH3:13])=[N:7][C:8]([N:2]([CH3:3])[CH3:1])=[N:9][CH:10]=1

参加物

3

反応物 2

HCID 674DimethylamineHCID 36631435-Bromo-2-chloro-4-methoxypyrimidine

生成物 1

HCID 6158295-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine収率 98.2%

反応条件

温度
45 °C

実験手順

A solution of dimethylamine (2.0 M solution in THF, 17.2 mL, 34.5 mmol) was added to 5-bromo-2-chloro-4-methoxypyrimidine (1.540 g, 6.89 mmol) at RT. The reaction was heated to 45° C. for 30 min, then cooled and concentrated. The residue was washed and filtered with diethyl ether to give 1.57 g of 5-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine as a light yellow solid. ES+=232.0 (M+H)

後処理

  1. temperaturecooled
  2. concentrationconcentrated
  3. washThe residue was washed
  4. filtrationfiltered with diethyl ether

出典と根拠

ORDレコード
ord-14e03286722344c0b75b5b4c102047d8
出典データセット
uspto-grants-2010_07
特許番号
US07759337B2

反応ノート

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