Hydrazine → HCID 178518953、化合物
反応式
Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=O)[C:11](=O)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:21][NH2:22]>>[CH2:2]([N:9]1[CH2:14][CH2:13][C:12]2[C:15]([OH:17])=[N:21][NH:22][C:11]=2[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
3
実験手順
A mixture of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (10.0 g, 34 mmol, Aldrich) and hydrazine (30 mL, 824 mmol, Aldrich) was stirred at RT for 48 h. The volatile solvents were removed in vacuo, and the residue was azeotroped with MeOH (1×), then recrystallized from MeOH to obtain the title compound MS (ESI, pos. ion) m/z: 230 (M+1).
後処理
- customThe volatile solvents were removed in vacuo
- customthe residue was azeotroped with MeOH (1×)
- customrecrystallized from MeOH
出典と根拠
- ORDレコード
- ord-c9d3f1878d6c4095b468ce2d115b40fb
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07759337B2
反応ノート
読み込み中…