化工社化工社 化学情報印刷レポート · 研究参考用
Benzoic Acid → 3-Nitro-5-sulfobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Benzoic acid, 3-sulfo- | HCID 8477 | — |
| 反応物 | Sulfur trioxide | HCID 24682 | — |
| 生成物 | 3-Nitro-5-sulfobenzoic acid | HCID 2749185 | — |
反応手順
Benzoic acid was sulfonated by heating it with concentrated sulfuric acid in the presence of sulfur trioxide. The 3-sulfobenzoic acid was nitrated with fuming nitric acid to yield 3-nitro-5-sulfobenzoic acid. Hydrogenation of this in 50% ethanol/water over palladium on charcoal easily afforded 3-amino-5-sulfobenzoic acid in good yield. Structural verification was obtained by carbon magnetic resonance, proton magnetic resonance and infra-red analysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04642240 |
| 出典データセット | uspto-grants-1987_02 |
| ORD ID | ord-747374bb87c74b8c8c7bfdc4ca2aba2a |
| 出典メモ | uspto-grants-1987_02 |