Water → HCID 59304580、化合物

HRID 2357877ノート

反応式

HRID 2357877 の反応式
[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9](=[S:14])[NH:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2].O.[CH3:17]N(C=O)C>>[CH2:1]([C:3]1[C:12]2[C:11](=[O:13])[NH:10][C:9]([S:14][CH3:17])=[N:8][C:7]=2[O:6][C:5](=[O:15])[CH:4]=1)[CH3:2]

参加物

4

反応物 3

HCID 962WaterHCID 6228DimethylformamideHCID 533226895-ethyl-2-mercapto-3H-pyrano[2,3-d]pyrimidine-4,7-dione

生成物 1

HCID 59304580HCID 59304580、化合物収率 96%

実験手順

Mel (2.23 mL, 35.72 mmol) was added to a suspension of 5-ethyl-2-thioxo-2,3-dihydro-1h-pyrano[2,3-d]pyrimidine-4,7-dione (4.0 g, 17.86 mmol) in DMF (40 mL) at room temperature. The reaction mixture was stirred at room temperature overnight. The reaction mixture was then poured into water (250 mL) and filtered through a sintered funnel. The solid residue was washed with water (2×50 mL) and dried under vacuum to give 5-ethyl-2-methylsulfanyl-3H-pyrano[2,3-d]pyrimidine-4,7-dione (4.1 g, 96%).

後処理

  1. filtrationfiltered through a sintered funnel
  2. washThe solid residue was washed with water (2×50 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-97fd655668d64ad5ae02c0b86fa9b5ab
出典データセット
uspto-grants-2010_07
特許番号
US07763623B2

反応ノート

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