Hydrochloric Acid → HCID 11536770、化合物
反応式
[Cl:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH:17]=1.Cl>[Pt]=O.CO>[Cl:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH3:19])[CH2:14][CH2:13]1参加物
5
実験手順
Preparation according to Example 3: 4-[2-chloro-3-(methylsulfonyl)phenyl]-1-ethyl-1,2,3,6-tetrahydropyridine (0.6 g, 2.0 mmol), methanol (25 ml), platinum oxide (0.15 g). Yield: 0.35 g (58%). The amine was converted to hydrochlorid acid salt and recrystallized from ethanol/diisopropyl ether: M.p. 264-265° C. MS m/z (relative intensity, 70 eV) 301 (M+, 6), 301 (13), 300 (11), 288 (35) 286 (bp).
後処理
- customPreparation
- customrecrystallized from ethanol/diisopropyl ether
出典と根拠
- ORDレコード
- ord-d5d83224af26416eaf003bd510dade29
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07763639B2
反応ノート
読み込み中…