関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 3-(Dimethylamino)benzoic acid | HCID 66837 | — |
| 反応物 | 2-Amino-7-phenoxy-1,8-naphthyridine | HCID 13787373 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(7-Phenoxy-1,8-naphthyridin-2-yl)-3-dimethylaminobenzamide | HCID 20217547 | 83.3% |
反応手順
The procedure is similar to that described in Example 1, but starting with 3-dimethylaminobenzoic acid (23.1 g), N,N'-carbonyldiimidazole (22.7 g) and 2-amino-7-phenoxy-1,8-naphthyridine (23.7 g). The product produced by precipitation in water (44 g; m.p. approximately 90° C.) is dissolved in boiling acetonitrile (1000 cc). After 3 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with acetonitrile (3×50 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-3-dimethylaminobenzamide (32 g) is produced (m.p. 120° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04642308 |
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| 出典データセット | uspto-grants-1987_02 |
|---|
| ORD ID | ord-10fe8bff54bd4a9784448665a62cc5e4 |
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| 出典メモ | uspto-grants-1987_02 |
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