N-Methylethylamine → 4-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

HRID 2358698ノート

反応式

HRID 2358698 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][NH:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([N:22]([CH2:23][CH3:24])[CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

参加物

4

反応物 2

HCID 12219N-MethylethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

生成物 1

HCID 684597124-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

The compound from Example 126c (1.0 g, 3.2 mmol) in CH2Cl2 was added to a mixture of N-methylethanamine (379 mg, 6.41 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving a yellow oil (1.03 g, 100%).

後処理

  1. concentrationMixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-b5950ceb20154c2c966813f1148fbd05
出典データセット
uspto-grants-2010_07
特許番号
US07763731B2

反応ノート

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