Stannous Chloride → 4-(2-amino-4-chlorophenoxy)-N-ethyl-N-methylbenzamide

反応式

[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:18]=[CH:17][C:10]([C:11]([N:13]([CH2:15][CH3:16])[CH3:14])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:21]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:21][C:4]1[CH:3]=[C:2]([Cl:1])[CH:20]=[CH:19][C:5]=1[O:6][C:7]1[CH:18]=[CH:17][C:10]([C:11]([N:13]([CH2:15][CH3:16])[CH3:14])=[O:12])=[CH:9][CH:8]=1

参加物

反応物 2

HCID 24479Stannous Chloride

HCID 684597124-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

生成物 1

HCID 684562034-(2-amino-4-chlorophenoxy)-N-ethyl-N-methylbenzamide収率 83%

実験手順

The product from Example 133a (1.0 g, 2.99 mmol) was reduced with SnCl2 following the procedure from Example 1f giving the title compound as a clear oil (751 mg, 83%).

出典と根拠

ORDレコード: ord-42f225324dba494fbe292161d77ae9cf
出典データセット: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07763731B2

反応ノート

読み込み中…