4-Methyl-2-nitroaniline → 2-Bromo-4-methyl-6-nitroaniline

HRID 2358775ノート

反応式

HRID 2358775 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[Br:12]Br>CC(O)=O.O>[Br:12][C:6]1[CH:7]=[C:2]([CH3:1])[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]=1[NH2:8]

参加物

5

反応物 2

HCID 69784-Methyl-2-nitroanilineHCID 24408Bromine

生成物 1

HCID 27753062-Bromo-4-methyl-6-nitroaniline

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

The title compound was prepared by dissolving 4-Methyl-2-nitro-phenylamine (20.0 g, 131 mmol) in 200 mL of HOAc. The reaction mixture was then heated to 100° C. until reaction mixture was homogeneous. At this point the reaction mixture was cooled to room temperature and Br2 (25.21 g, 157 mmol) was added drop wise over the course of 10 minutes. An orange solid formed, and upon completion of the addition the reaction mixture was diluted with water and the title compound collected by filtration (29 g, 96%).

後処理

  1. temperatureAt this point the reaction mixture was cooled to room temperature
  2. customAn orange solid formed
  3. additionupon completion of the addition the reaction mixture
  4. filtrationthe title compound collected by filtration (29 g, 96%)

出典と根拠

ORDレコード
ord-44c707fdd0c64c00850e76aaae35b142
出典データセット
uspto-grants-2010_07
特許番号
US07763731B2

反応ノート

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