2-Nitro-biphenyl-4-carboxylic acid methyl ester → Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

HRID 2358805

反応式

HRID 2358805 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([N+:17]([O-])=O)[CH:6]=1)=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:7]([NH2:17])[CH:6]=1)=[O:4]

参加物

3

反応物 1

HCID 121698042-Nitro-biphenyl-4-carboxylic acid methyl ester

生成物 1

HCID 67497797Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The product from Example 212b (0.0795 g, 0.309 mmol) was dissolved in ethanol (2 mL) and to this solution was added Pt(IV) oxide (5.2 mg). The reaction mixture was vacuum degassed then exposed to one atmosphere of hydrogen for 3 h at room temperature. The catalyst was removed by filtration through celite and the filtrate concentrated under vacuum to give the title compound in quantitative yield.

後処理

  1. customdegassed
  2. customThe catalyst was removed by filtration through celite
  3. concentrationthe filtrate concentrated under vacuum

出典と根拠

ORDレコード
ord-f53744894b0144d3985e50101d84997a
出典データセット
uspto-grants-2010_07
特許番号
US07763731B2

関連ノート

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