Potassium Hydroxide → 5-(Furan-3-yl)-1,3-oxazole-4-carboxylic acid
反応式
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([O:13]C)=[O:12])=[CH:2]1.[OH-].[K+]>CO>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([OH:13])=[O:12])=[CH:2]1参加物
4
実験手順
3 g of methyl 5-(3-furyl)oxazole-4-carboxylate and 2.6 g of 85% potassium hydroxide are dissolved in 100 ml of methanol, and the solution is stirred at room temperature overnight. Then, the reaction mixture is evaporated under reduced pressure to remove solvent, and the residue is acidified with dil. hydrochloric acid. The precipitated crystals are collected by filtration, washed with cold water and then dried. 2.6 g of 5-(3-furyl)oxazole-4-carboxylic acid are thereby obtained. Yield: 93.7%
後処理
- customThen, the reaction mixture is evaporated under reduced pressure
- customto remove solvent
- filtrationThe precipitated crystals are collected by filtration
- washwashed with cold water
- customdried
出典と根拠
- ORDレコード
- ord-47f38b7fbd97494f9e212cac11356d8f
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04642313
反応ノート
読み込み中…