Benzylamine → HCID 67261084、化合物

HRID 2359042ノート

反応式

HRID 2359042 の反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]2[C:11]([C:12]3[CH:17]=[CH:16][N:15]=[C:14](S(C)(=O)=O)[N:13]=3)=[CH:10][N:9]([CH:22]([CH3:24])[CH3:23])[N:8]=2)=[CH:4][CH:3]=1.[CH2:25]([NH2:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:25]([NH:32][C:14]1[N:13]=[C:12]([C:11]2[C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:8][N:9]([CH:22]([CH3:24])[CH3:23])[CH:10]=2)[CH:17]=[CH:16][N:15]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

3

反応物 2

HCID 7504BenzylamineHCID 67260704HCID 67260704、化合物

生成物 1

HCID 67261084HCID 67261084、化合物収率 96%

実験手順

A mixture of 4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]-2-(methylsulfonyl)pyrimidine (1 eq, 5.2 mmol) in 25 mL benzylamine was stirred overnight at room temperature. The solvent was evaporated and the residue was diluted in dichloromethane and washed three times with HCl 1M. The organic layer was then dried over MgSO4 and evaporated to afford 2.3 g of N-benzyl-4-[3-(5-chloro-2-thienyl)-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-amine (96% yield).

後処理

  1. customThe solvent was evaporated
  2. additionthe residue was diluted in dichloromethane
  3. washwashed three times with HCl 1M
  4. dry with materialThe organic layer was then dried over MgSO4
  5. customevaporated

出典と根拠

ORDレコード
ord-69a9e99851844966ba2b881130057480
出典データセット
uspto-grants-2014_04
特許番号
US08685974B2

反応ノート

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