4-Fluorobenzoyl chloride → 4-Fluoro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

反応式

Cl.[O:2]1[CH:6]=[CH:5][C:4]([C:7]([CH2:9][NH2:10])=[O:8])=[CH:3]1.C(=O)(O)[O-].[Na+].[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:10][CH2:9][C:7]([C:4]2[CH:5]=[CH:6][O:2][CH:3]=2)=[O:8])=[O:22])=[CH:19][CH:18]=1

参加物

反応物 3

HCID 678794-Fluorobenzoyl chloride

HCID 516892Sodium Bicarbonate

HCID 137731212-Amino-1-(furan-3-yl)ethan-1-one--hydrogen chloride (1/1)

生成物 1

HCID 137870254-Fluoro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide収率 92.6%

実験手順

6.0 g of (3-furylcarbonyl)methylamine hydrochloride, 7.8 g of sodium bicarbonate and 6.4 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(1). 8.5 g of N-(4-fluorobenzoyl)-(3-furylcarbonyl)methylamine are thereby obtained. Yield: 92.4%

後処理

customas described in Preparation 1-(1)

出典と根拠

ORDレコード: ord-8431e73f4d51469293ed1c6e753fbe13
出典データセット: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04642313

反応ノート

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