Dimethylformamide dimethyl acetal → HCID 67260579、化合物

HRID 2359062

反応式

HRID 2359062 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[CH3:12][N:13]([CH3:15])[CH:14]=[CH:8][C:7]([C:4]1[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=1)=[O:9]

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 836541-(4-Methyl-2-thienyl)ethan-1-one

生成物 1

HCID 67260579HCID 67260579、化合物収率 100%

実験手順

A mixture of 1-(4-methyl-2-thienyl)ethanone (70.8 mmol) and N,N-dimethylformamide dimethyl acetal (105.1 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 13.8 g (100% yield) of 3-(dimethylamino)-1-(4-methyl-2-thienyl)prop-2-en-1-one which was used in the next step without further purification.

後処理

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-5059afaa48714899a0071ff605fd7a13
出典データセット
uspto-grants-2014_04
特許番号
US08685974B2

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