Methyl bromoacetate → methyl 2-[N-(2-cyclohex-1-enyl)ethylamino]acetate
反応式
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:7]1([CH2:13][CH2:14][NH2:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]=1>C(Cl)Cl>[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][C:7]=1[CH2:13][CH2:14][NH:15][CH2:2][C:3]([O:5][CH3:6])=[O:4]参加物
4
実験手順
To a solution of methyl bromoacetate (5 g, 32.7 mmol) in DCM (150 mL) was added 2-(1-cyclohexenyl)ethylamine (11.4 ml, 81.71 mmol) over 5 min. After 2 h, the solvent was removed and the residue purified on silica gel (Merck 60; (1:9) ethyl acetate/hexane) to afford methyl 2-[N-(2-cyclohex-1-enyl)ethylamino]acetate (5.0 g, 78%).
後処理
- customthe solvent was removed
- customthe residue purified on silica gel (Merck 60; (1:9) ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-2836cb80e50c435098e844f743189272
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06852752B2
反応ノート
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