関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Glycidol | HCID 11164 | — |
| 反応物 | 1-Methyl-3-phenylpropylamine | HCID 31160 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 3-(1-Phenyl-3-butyl)amino-1,2-propanediol | HCID 5195560 | 70% |
反応手順
A solution of glycidol (11.5 g, 0.155 mol) in isopropanol (25 ml) was added dropwise under N2 at 40° C. to a solution of 1-phenyl-3-butylamine in isopropanol (50 ml). After 1 hour, the solution was heated at 70° C. for 1.5 hours and then at room temperature overnight. The isopropanol was removed under reduced pressure and the residue distilled to yield 24 g (70%) of 94; b.p.0.2 140°-5° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04642311 |
|---|
| 出典データセット | uspto-grants-1987_02 |
|---|
| ORD ID | ord-8c87308af1624cf29f8cadda2a8146a7 |
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| 出典メモ | uspto-grants-1987_02 |
|---|
