関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzene, 1-chloro-3-isocyanato- | HCID 17968 | — |
| 反応物 | 3-(2-Chloroethyl)-1,3-oxazolidin-2-one | HCID 75633 | — |
| 触媒 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3-chlorophenyl)-N'-(2-chloroethyl)imidazolidinone | HCID 13824503 | 78.7% |
反応手順
A mixture of 3-chlorophenyl isocyanate (7.65 g, 50 mmoles), N-(2-chloroethyl)-2-oxazolidinone (7.5 g, 50 mmoles) and anhydrous AlCl3 (40 mg, 0.3 mmole) is heated at 195° C. for 6 hours with stirring. The reaction mixture is dissolved in dichloromethane and the resulting solution is washed with water twice. The dichloromethane solution is dried and evaporated and the residue distilled at reduced pressure. The distillate is recrystallized from hot hexane to give 10.2 g (78.4 percent) of the desired product, m.p. 64° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04642351 |
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| 出典データセット | uspto-grants-1987_02 |
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| ORD ID | ord-94979adb2c224e2eab50346924169805 |
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| 出典メモ | uspto-grants-1987_02 |
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