4-Methylmorpholine → N-{6-[1-(Pyridin-3-yl)-1H-pyrazol-4-yl]pyridin-2-yl}methanesulphonamide

反応式

[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[C:10]([C:12]3[N:17]=[C:16]([NH2:18])[CH:15]=[CH:14][CH:13]=3)[CH:9]=[N:8]2)[CH:2]=1.CN1CCOCC1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH:11]=[C:10]([C:12]3[N:17]=[C:16]([NH:18][S:27]([CH3:26])(=[O:29])=[O:28])[CH:15]=[CH:14][CH:13]=3)[CH:9]=[N:8]2)[CH:2]=1

参加物

実験手順

146 mg (585 μmol) of 6-[1-(pyridin-3-yl)-1H-pyrazol-4-yl]pyridine-2-amine and 54.0 μl (701 μmol) of N-methylmorpholine were initially charged in 10 ml of dichloromethane, and methanesulphonyl chloride was added at room temperature. The mixture was stirred overnight and the reaction mixture was filtered through silica gel (eluent: ethyl acetate). After concentration, the crude product was purified by chromatography (dichloromethane/methanol).