Hydrogen chloride-ethyl acetate → HCID 67004062、化合物
反応式
[CH3:1][N:2]([CH2:10][C:11]1[S:12][C:13]([S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:15]=1)C(=O)OC(C)(C)C.C(OCC)(=O)C.[ClH:37]>C(O)C>[ClH:37].[CH3:1][NH:2][CH2:10][C:11]1[S:12][C:13]([S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:15]=1参加物
4
実験手順
To a solution of tert-butyl methyl{[4-phenyl-5-(phenylsulfonyl)-1,3-thiazol-2-yl]methyl}carbamate (0.18 g) in ethanol (2 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (2 mL) at room temperature, and the mixture was stirred for 14 hr. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound as white crystals (yield 80 mg, 53%).