Ethyl 2-cyano-2-(hydroxyimino)acetate → 7-AMINO-1-[(4-CHLOROPHENYL)METHYL]-2,3-DIHYDRO-6-NITROSOIMIDAZO-[1,2-a]PYRIMIDIN-5-(1H)-ONE

HRID 236012

反応式

HRID 236012 の反応式
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[CH2:14][CH2:13][N:12]=[C:11]2[NH2:15])=[CH:5][CH:4]=1.[N:16](=[C:18]([C:24]#[N:25])[C:19](OCC)=[O:20])[OH:17]>>[NH2:25][C:24]1[N:15]=[C:11]2[N:10]([CH2:9][C:6]3[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=3)[CH2:14][CH2:13][N:12]2[C:19](=[O:20])[C:18]=1[N:16]=[O:17]

参加物

3

反応物 2

HCID 6399078Ethyl 2-cyano-2-(hydroxyimino)acetateHCID 202177121-[(4-Chlorophenyl)methyl]-4,5-dihydro-1H-imidazol-2-amine hydrochloride2 回

生成物 1

HCID 133914207-AMINO-1-[(4-CHLOROPHENYL)METHYL]-2,3-DIHYDRO-6-NITROSOIMIDAZO-[1,2-a]PYRIMIDIN-5-(1H)-ONE

実験手順

The product of Procedure 91 was condensed with ethyl oximinocyanoacetate according to the method described in Procedure 1. The crude product, 1.6 g., from 2.9 g. of the product of Procedure 91, was a blue solid, m.p. 273°-275° d, recrystallized from dimethylformamide, m.p. 290°-291° d.

後処理

  1. customrecrystallized from dimethylformamide, m.p. 290°-291°

出典と根拠

ORDレコード
ord-cced221111dc4956830f74cca61be129
出典データセット
uspto-grants-1987_02
特許番号
US04642345

関連ノート

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