Hydrogen chloride-ethyl acetate → (Cyclohexylmethyl)(methyl)amine hydrochloride
反応式
[CH:1]1([CH2:7][N:8](C)[C:9](=O)OC(C)(C)C)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:17].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:17].[CH:1]1([CH2:7][NH:8][CH3:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
To a solution of tert-butyl N-(cyclohexylmethyl)-N-methylcarbamate (370 mg, 1.6 mmol) in 4.0 mL of ethyl acetate was added 4 M HCl-ethyl acetate (4 mL). After being stirred at room temperature for 1.5 h, the reaction mixture was concentrated in vacuo, and the residue was rinsed with hexane to obtain the title compound (266 mg, 100%).
後処理
- concentrationthe reaction mixture was concentrated in vacuo
- washthe residue was rinsed with hexane
出典と根拠
- ORDレコード
- ord-93b77bf83ce045ec8da2cbc16bcb0bb2
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08686024B2
反応ノート
読み込み中…