Hydrochloric Acid → 3,3-Dimethyl-1-(phenylmethyl)piperazine
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][C:9]1([CH3:22])[CH3:21])=O)(C)(C)C.Cl>CO>[CH2:14]([N:11]1[CH2:12][CH2:13][NH:8][C:9]([CH3:22])([CH3:21])[CH2:10]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1参加物
4
実験手順
3.30 g 4-Benzyl-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 50 ml methanol, and 25 ml of 1N aqueous hydrochloric acid were added. After stirring overnight 5 ml of concentrated aqueous hydrochloric acid were added. After 2 h the volatiles were removed in vacuo and 2.40 g (97%) of the title compound were obtained as hydrochloride salt, which could be use without further purification.
後処理
- additionwere added
- customAfter 2 h the volatiles were removed in vacuo
出典と根拠
- ORDレコード
- ord-338dd4a49672496aa76736a1cd0ee2ef
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08686150B2
反応ノート
読み込み中…