関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | 1-Chloro-4-phenylphthalazine | HCID 272109 | — |
| 反応物 | 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine | HCID 66735161 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Sodium Carbonate | HCID 10340 | — |
| 生成物 | N-(4-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-4-phenylphthalazin-1-amine | HCID 57756271 | — |
反応手順
To 4-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyridin-2-amine (0.070 g, 0.24 mmol) and 1-chloro-4-phenylphthalazine (0.048 g, 0.20 mmol) was added tBuOH (1.0 mL). The resulting mixture was heated at 100° C. in a sealed tube for 16 hours. The reaction was diluted with diethyl ether and saturated sodium carbonate and vigorously shaken. The resulting solids were filtered and washed with water, diethyl ether and air dried to yield N-(4-(3-(2-(methylamino)pyridin-4-yl)pyridin-2-yloxy)phenyl)-4-phenylphthalazin-1-amine as an off-white solid. MS m/z=497 [M+H]+. Calc'd for C31H24N6O: 496.58.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08686155B2 |
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| 出典データセット | uspto-grants-2014_04 |
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| ORD ID | ord-e396a48e028243ec828c936e5857f4be |
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| 出典メモ | uspto-grants-2014_04 |
|---|
