Triethylamine → HCID 58362653、化合物
反応式
Cl.[NH:2]1[CH2:5][CH:4]([OH:6])[CH2:3]1.Br[C:8]1[CH:13]=[CH:12][N:11]2[C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=[C:10]2[N:9]=1.C(N(CC)CC)C>O>[N:9]1[C:10]2[N:11]([C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[CH:12]=[CH:13][C:8]=1[N:2]1[CH2:5][CH:4]([OH:6])[CH2:3]1参加物
5
実験手順
Azetidin-3-ol hydrochloride (0.022 g, 0.202 mmol), 2-bromobenzo[4,5]imidazo[1,2-a]pyrimidine (0.05 g, 0.202 mmol) and Triethylamine (0.028 ml, 0.202 mmol) were heated to 100° C. for 10 minutes in a microwave. Let the reaction cool to room temperature. Diluted with water and vacuum filtered ppt. Washed with water to afford 1-(benzo[4,5]imidazo[1,2-a]pyrimidin-2-yl)azetidin-3-ol (0.048 g, 0.200 mmol, 99% yield).
後処理
- filtrationfiltered ppt
- washWashed with water
出典と根拠
- ORDレコード
- ord-9358c207fa2c43d69b3668ad06e20f5f
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691187B2
反応ノート
読み込み中…