Hydrochloric Acid → Hydrochloric Acid
反応式
[O:1]=[C:2]1[CH:9]2[CH2:10][C:5]3([NH:12]C(=O)C)[CH2:6][CH:7]([CH2:11][CH:3]1[CH2:4]3)[CH2:8]2.[ClH:16]>>[NH2:12][C:5]12[CH2:10][CH:9]3[CH2:8][CH:7]([CH2:11][CH:3]([C:2]3=[O:1])[CH2:4]1)[CH2:6]2.[ClH:16]参加物
4
実験手順
A solution of N-(4-oxoadamantan-1-yl)acetamide (1A) (20 mmol) in 200 mL of concentrated, aqueous HCl was heated in a sealed pressure tube at 130° C. for 20 h. The solvent was removed under reduced pressure to give amine 1B as an HCl salt in 90% yield as an off-white solid. Data: LC/MS (ESR) m/z 166 [M+1]+.
後処理
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-a2510aca39bb4a17a42d33a8c433a65f
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691808B2
反応ノート
読み込み中…