5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde → (S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine

HRID 2361968ノート

反応式

HRID 2361968 の反応式
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH2:7])[CH3:6])[CH3:2].[Cl:11][C:12]1[N:17]=[C:16]2[C:18]([CH:21]=O)=[CH:19][S:20][C:15]2=[CH:14][CH:13]=1>>[Cl:11][C:12]1[N:17]=[C:16]2[C:18]([CH2:21][NH:7][C@@H:5]([CH3:6])[CH:4]([O:8][CH2:9][CH3:10])[O:3][CH2:1][CH3:2])=[CH:19][S:20][C:15]2=[CH:14][CH:13]=1

参加物

3

反応物 2

HCID 14762645-Chlorothieno[3,2-b]pyridine-3-carbaldehydeHCID 12398111(2S)-1,1-Diethoxy-2-propanamine

生成物 1

HCID 86652569(S)-N-((5-chlorothieno[3,2-b]pyridin-3-yl)methyl)-1,1-diethoxypropan-2-amine収率 30.3%

実験手順

According to the procedure described in the synthesis method of Compound IX-6, (S)-1,1-diethoxypropan-2-amine (Compound XVIII-1) (1.98 g, 13.4 mmol) was reacted with 5-chlorothieno[3,2-b]pyridine-3-carbaldehyde (Compound XIX-1) (1.98 g, 10 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2 to 95:5) to obtain the title compound (996 mg, 30%).

後処理

  1. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: chloroform:methanol=98:2 to 95:5)

出典と根拠

ORDレコード
ord-5abf3cde6b0f49049bea6d8574a50cc9
出典データセット
uspto-grants-2014_04
特許番号
US08691819B2

反応ノート

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