2-Pyridinemethanamine → N-(2,2-diethoxyethyl)pyridine-2-methylamine

反応式

Br[CH2:2][CH:3]([O:7][CH2:8][CH3:9])[O:4][CH2:5][CH3:6].[N:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][NH2:17]>>[CH2:5]([O:4][CH:3]([O:7][CH2:8][CH3:9])[CH2:2][NH:17][CH2:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][N:10]=1)[CH3:6]

参加物

反応物 2

HCID 195092-Pyridinemethanamine

HCID 74852Ethane, 2-bromo-1,1-diethoxy-

生成物 1

HCID 81407N-(2,2-diethoxyethyl)pyridine-2-methylamine収率 65.9%

実験手順

According to the procedure described in the synthesis method of Compound IX-1, 2-bromo-1,1-diethoxyethane (34.6 ml, 230 mmol) was reacted with 2-picolylamine (50 g, 460 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: ethyl acetate:ethanol=10:1) to obtain the title compound (34.0 g, 65%)

後処理

customthe obtained residue was purified by silica gel column chromatography (eluent: ethyl acetate:ethanol=10:1)

出典と根拠

ORDレコード: ord-9dd53fad2df0445491ca1329595219f7
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08691819B2

反応ノート

読み込み中…

参加物