Dimethylformamide dimethyl acetal → HCID 66719111、化合物

HRID 2362149ノート

反応式

HRID 2362149 の反応式
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:26])[CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:28][N:29]([CH:31](OC)OC)[CH3:30]>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:18](=[O:26])[C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:28][N:29]([CH3:31])[CH3:30])=[CH:16][CH:17]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 57805516tert-Butyl {1-[4-(phenylacetyl)phenyl]cyclobutyl}carbamate

生成物 1

HCID 66719111HCID 66719111、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of compound 1-3 (5.0 g, 13.7 mmol) in toluene (30 mL) was added DMFDMA (18.15 g, 68.4 mmol) and the mixture was heated at reflux for 4 hours. The TLC showed the starting material was disappeared. The mixture was cooled and the formed white solid was collected. After washed by PE, the solid was dried in vacuum to get the product 1.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 hours
  3. temperatureThe mixture was cooled
  4. customthe formed white solid was collected
  5. washAfter washed by PE
  6. customthe solid was dried in vacuum

出典と根拠

ORDレコード
ord-8c6d2d1f2ffe48f480172971da07ad95
出典データセット
uspto-grants-2014_04
特許番号
US08691825B2

反応ノート

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