Ammonium Hydroxide → 5-Amino-2-thiophenecarboxamide
反応式
C[O:2][C:3]([C:5]1[S:6][C:7]([NH2:10])=[CH:8][CH:9]=1)=O.[NH4+:11].[OH-]>>[NH2:10][C:7]1[S:6][C:5]([C:3]([NH2:11])=[O:2])=[CH:9][CH:8]=1参加物
3
反応条件
- 温度
- 60 °C
実験手順
A 18 ml vial was loaded with 5-amino-thiophene-2-carboxylic acid methylester (250 mg, 1.59 mmole) and 5 ml of 30% NH4OH. The vial was sealed and the mixture was heated at 60° C. for 24 hours. The mixture was cooled down and concentrated to give 200 mg crude product, 47.4% yield.
後処理
- customThe vial was sealed
- temperatureThe mixture was cooled down
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b42d4bcdf5fd4421a3d8a0ce646d6f1f
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691816B2
反応ノート
読み込み中…