Cyclobutanone → N-cyclobutylidene-1-(4-methoxyphenyl)methanamine

HRID 2362712ノート

反応式

HRID 2362712 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1.[C:11]1(=O)[CH2:14][CH2:13][CH2:12]1>C(OCC)C>[C:11]1(=[N:10][CH2:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 14496CyclobutanoneHCID 754524-Methoxybenzylamine

生成物 1

HCID 58513739N-cyclobutylidene-1-(4-methoxyphenyl)methanamine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of (4-methoxyphenyl)methanamine (9.26 mL, 71.3 mmol) and cyclobutanone (5.35 mL, 71.3 mmol) in anhydrous ethyl ether (70 mL) was treated with activated 4 angstrom molecular sieves (2.5 g). The mixture was stirred vigorously for 16 hours at ambient temperature. The reaction mixture was filtered, and the sieves were washed with ethyl ether. The filtrate was concentrated under reduced pressure with no heat. The title compound was stored under nitrogen and used without further purification. MS DCI(+) m/z 190.3 [M+H]+.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washthe sieves were washed with ethyl ether
  3. concentrationThe filtrate was concentrated under reduced pressure with no heat
  4. customused without further purification

出典と根拠

ORDレコード
ord-f1d9da33223342feba165a1c3aef4ef6
出典データセット
uspto-grants-2014_04
特許番号
US08691810B2

反応ノート

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