Lithium hydroxide, monohydrate → Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

HRID 2362776ノート

反応式

HRID 2362776 の反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])(=[O:14])=[O:13])[CH2:7]1)=[O:5])C.O[Li:23].O>C1COCC1.CO.O>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([N:8]1[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([O-:5])=[O:3])[CH2:7]1)(=[O:13])=[O:14].[Li+:23]

参加物

4

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 38620101-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester

生成物 1

HCID 67131265Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

試薬・触媒・溶媒 1

HCID 21892291Methanol tetrahydrofuran water溶媒

実験手順

To a solution of 5.7 g 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester (17 mmol) in 30 mL THF: methanol:water (2:1:1) was added 1.08 g LiOH H2O (25.7 mmol). The mixture was stirred at room temperature for 5-6 h and all volatiles were evaporated to dryness. The compound was used in the consecutive step without further purification.

後処理

  1. customall volatiles were evaporated to dryness
  2. customThe compound was used in the consecutive step without further purification

出典と根拠

ORDレコード
ord-79f7c542e757489bbeaf0e7b8d53ac26
出典データセット
uspto-grants-2014_04
特許番号
US08691846B2

反応ノート

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