Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2362805ノート

反応式

HRID 2362805 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

生成物 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone収率 83%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction mixture was stirred overnight at room temperature and was then concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D6 (2.0 g, 83%).

後処理

  1. concentrationwas then concentrated in vacuo
  2. customThe crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

出典と根拠

ORDレコード
ord-32c1fd10ba544846ad7a947bf40dba39
出典データセット
uspto-grants-2014_04
特許番号
US08691849B2

反応ノート

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