Hydrochloric Acid → HCID 136066331、化合物

HRID 236282ノート

反応式

HRID 236282 の反応式
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:14][O:15][CH2:16][CH2:17][O:18][C:19]1[CH:20]=[N:21][NH:22][CH:23]=1.O.Cl>CN(C)C=O>[CH3:14][O:15][CH2:16][CH2:17][O:18][C:19]1[CH:20]=[N:21][N:22]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=2)[CH:23]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 135633474-(2-Methoxyethoxy)-1H-pyrazoleHCID 1354271042-(Methylsulfanyl)quinazolin-4(1H)-one

生成物 1

HCID 136066331HCID 136066331、化合物収率 58.5%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

96 g (0.5 mole) of 2-methylthio-4(3H)-quinazolinone are stirred in 250 ml of dimethylformamide with 142 g (1 mole) of 4-(β-methoxy-ethoxy)pyrazole at the reflux temperature for 40 hours. After cooling, 2.5 litres of water are added and a pH value of 3 is established with hydrochloric acid. The crude product which separates out (97.3 g of melting point 119°-24°) is recrystallized from isopropanol. 83.8 g of 2-(4-β-methoxyethoxy-1H-pyrazol-1-yl)-4(3H)-quinazolinone of melting point 125° to 127° C. are obtained.

後処理

  1. temperatureAfter cooling
  2. customis recrystallized from isopropanol

出典と根拠

ORDレコード
ord-907e8ea32f5841feb1027446b48fdfae
出典データセット
uspto-grants-1987_02
特許番号
US04644000

反応ノート

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