2-Bromo-4'-(trifluoromethyl)acetophenone → HCID 86633307、化合物
反応式
[CH:1](=[N:10][NH:11][C:12]([NH2:14])=[S:13])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1)=O>>[F:26][C:25]([F:27])([F:28])[C:22]1[CH:21]=[CH:20][C:19]([C:17]2[N:14]=[C:12]([NH:11][N:10]=[CH:1][CH:2]=[CH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[S:13][CH:16]=2)=[CH:24][CH:23]=1参加物
3
実験手順
The compound is prepared according to the method described in Example 1B from cinnamaldehyde thiosemicarbazone (0.5 mmol) (Eur. J. Med. Chem. 25(7), 581-588, 1990) and from 2-bromo-4′-trifluoromethylacetophenone (0.5 mmol) (Tet., 59(8) 1317-1325, 2003). Yield 42%.
後処理
- customThe compound is prepared
出典と根拠
- ORDレコード
- ord-1230b79c1ad641c8ad14a8d518784cb5
- 出典データセット
- uspto-grants-2014_04
- DOI