Cinnamaldehyde, thiosemicarbazone → HCID 15950491、化合物

反応式

[CH:1](=[N:10][NH:11][C:12]([NH2:14])=[S:13])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Br[CH2:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=1[CH3:26])=O>>[CH3:26][C:20]1[CH:21]=[C:22]([OH:25])[CH:23]=[CH:24][C:19]=1[C:17]1[N:14]=[C:12]([NH:11]/[N:10]=[CH:1]/[CH:2]=[CH:3]/[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[S:13][CH:16]=1

参加物

反応物 2

HCID 2737765Cinnamaldehyde, thiosemicarbazone

HCID 178121702-Bromo-1-(4-hydroxy-2-methylphenyl)ethanone

生成物 1

HCID 15950491HCID 15950491、化合物収率 36%

実験手順

The compound is prepared according to the method described in example 1B from cinnamaldehyde thiosemicarbazone (0.28 mmoles) (Eur. J. Med. Chem. 25(7), 581-588, 1990) and from 2-bromo-4′-hydroxy-2′-methylacetophenone (0.28 mmoles). Yield 36%.

後処理

customThe compound is prepared

出典と根拠

ORDレコード: ord-7a3c8a3399034aa49a16fe97c0101eb6
出典データセット: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08691854B2

反応ノート

読み込み中…

参加物