Ammonium Chloride → 3-cyclobutylphenol

HRID 2363146ノート

反応式

HRID 2363146 の反応式
[CH:1]1([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11]C)[CH:6]=2)[CH2:4][CH2:3][CH2:2]1.[Cl-].[NH4+]>C(Cl)Cl>[CH:1]1([C:5]2[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=2)[CH2:2][CH2:3][CH2:4]1

参加物

4

反応物 2

HCID 25517Ammonium ChlorideHCID 58319227HCID 58319227、化合物

生成物 1

HCID 179184093-cyclobutylphenol収率 71%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a suspension of 1-cyclobutyl-3-methoxy-benzene (155 mg, 0.95 mmol) in CH2Cl2 (2 mL) was added dropwise 1.0M-BBr2 (1.05 mL, 1.05 mmol) at 0° C. The mixture was stirred for 1 hour at 0° C., treated with saturated ammonium chloride, and then extracted with CH2Cl2. The organic layer was dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by column chromatography to give 3-cyclobutyl-phenol (100 mg, 71%).

後処理

  1. additionwas added dropwise 1.0M-BBr2 (1.05 mL, 1.05 mmol) at 0° C
  2. extractionextracted with CH2Cl2
  3. dry with materialThe organic layer was dried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe crude product was purified by column chromatography

出典と根拠

ORDレコード
ord-e4862231c4844d1e8c605f08681077f5
出典データセット
uspto-grants-2014_04
特許番号
US08691855B2

反応ノート

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