関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 2-bromopropionate | HCID 79040 | — |
| 反応物 | 7-Hydroxyisoflavone | HCID 5376891 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl 2-[(4-oxo-3-phenyl-4H-chromen-7-yl)oxy]propionate | HCID 3579826 | 181.3% |
反応手順
A mixture of 40 g of 7-hydroxy-3-phenyl-4H-1-benzopyran-4-one, 46 g of ethyl 2-bromopropionate, 250 ml of dimethylformamide and 46.5 g of potassium carbonate was stirred well with heating at 80° C. for 2 hours and poured into 270 ml of ice water. The resulting crystalline precipitate was collected by filtration and recrystallized from ethyl acetate-ethanol to give 103 g of 7-(1-ethoxycarbonylethyl)oxy-3-phenyl-4H-1-benzopyran-4-one as white crystals. m.p. 165°-166° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04644012 |
|---|
| 出典データセット | uspto-grants-1987_02 |
|---|
| ORD ID | ord-23d214a5cf28460687112731cb37a5d4 |
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| 出典メモ | uspto-grants-1987_02 |
|---|
