関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Ethyl 2-bromopropionate | HCID 79040 | — |
| 反応物 | Daidzein | HCID 5281708 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-(1-ethoxy-carbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one | HCID 86741309 | 54.1% |
反応手順
A mixture of 4.0 g of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 3.42 g of ethyl 2-bromopropionate, 60 ml of dimethylformamide and 4.3 g of potassium carbonate was stirred well with heating at 80° C. for 2 hours, poured into ice water and extracted with ethyl acetate. The extract was washed with water and concentrated and the residue was recrystallized from dichloroethane to give 3.0 g of 7-(1-ethoxy- carbonylethyl)oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one as white crystals. m.p. 172°-173° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04644012 |
|---|
| 出典データセット | uspto-grants-1987_02 |
|---|
| ORD ID | ord-122f3f1eb7e848a48d97ae0877aab56c |
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| 出典メモ | uspto-grants-1987_02 |
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