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Hydrochloric Acid → 2-((4-Oxo-3-phenyl-4H-1-benzopyran-7-yl)oxy)propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Ethyl 2-[(4-oxo-3-phenyl-4H-chromen-7-yl)oxy]propionate | HCID 3579826 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-((4-Oxo-3-phenyl-4H-1-benzopyran-7-yl)oxy)propanoic acid | HCID 3062797 | 93.2% |
反応手順
A mixture of 20 g of 7-(1-ethoxycarbonylethyl)oxy-3-phenyl-4H-1-benzopyran-4-one, 200 ml of dioxane, 70 ml of hydrochloric acid and 150 ml of water was refluxed for 4 hours and poured into ice water. The resulting crystalline precipitate was collected by filtration and recrystallized from ethanol to give 17.1 g of 7-(1-hydroxycarbonylethyl)oxy-3-phenyl-4H-1-benzopyran-4-one as white crystals. m.p. 223° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04644012 |
| 出典データセット | uspto-grants-1987_02 |
| ORD ID | ord-ce9c24a4f6ea45f18a9d5252defdb5da |
| 出典メモ | uspto-grants-1987_02 |