Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid

HRID 236370

反応式

HRID 236370 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH:18](C(OCC)=O)[C:19]([O:21]CC)=[O:20])([O-:3])=[O:2].Cl>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=[O:20])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13408230Diethyl 2-nitro-4-benzoylphenylmalonate

生成物 1

HCID 137705362-Nitro-4-benzoylphenylacetic acid収率 95%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.

後処理

  1. additionA mixture of 14 g
  2. temperatureto reflux for 10 hours
  3. concentrationThe reaction mixture was concentrated in vacuo
  4. customthe crude product was triturated with hot methylene chloride, 9.88 g

出典と根拠

ORDレコード
ord-d19d22f9d8d14e5bb46699305da9114a
出典データセット
uspto-grants-1987_02
特許番号
US04644005

関連ノート

読み込み中…