Hydrochloric Acid → 2-Nitro-4-benzoylphenylacetic acid
反応式
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH:18](C(OCC)=O)[C:19]([O:21]CC)=[O:20])([O-:3])=[O:2].Cl>O1CCOCC1>[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([OH:21])=[O:20])([O-:3])=[O:2]参加物
4
実験手順
A mixture of 14 g. (36.3 mmoles) of diethyl 2-nitro-4-benzoylphenylmalonate, 300 ml. of 4N hydrochloric acid and 300 ml. of dioxane was heated to reflux for 10 hours. The reaction mixture was concentrated in vacuo and the crude product was triturated with hot methylene chloride, 9.88 g. (95% yield), m.p. 168°-170° C.
後処理
- additionA mixture of 14 g
- temperatureto reflux for 10 hours
- concentrationThe reaction mixture was concentrated in vacuo
- customthe crude product was triturated with hot methylene chloride, 9.88 g
出典と根拠
- ORDレコード
- ord-d19d22f9d8d14e5bb46699305da9114a
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04644005
反応ノート
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