Ethyl 2-nitro-4-benzoylphenylacetate → Ethyl 2-amino-4-benzoylphenylacetate

HRID 236372

反応式

HRID 236372 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])([O-])=O>[Ni].C(O)C>[NH2:1][C:4]1[CH:9]=[C:8]([C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]

参加物

4

反応物 1

HCID 13770535Ethyl 2-nitro-4-benzoylphenylacetate

生成物 1

HCID 13770537Ethyl 2-amino-4-benzoylphenylacetate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

To a solution of 14 g. (44.7 mmoles) of ethyl 2-nitro-4-benzoylphenylacetate in 225 ml. of ethanol was added 15 g. of wet Raney nickel and the mixture heated to reflux for 1.5 hours. The mixture was filtered and the filtrate concentrated to give a residual oil which was induced to crystallize by trituration with diethyl ether, 7.9 g., m.p. 150°-152° C.

後処理

  1. temperatureto reflux for 1.5 hours
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated
  4. customto give a residual oil which
  5. customto crystallize by trituration with diethyl ether, 7.9 g

出典と根拠

ORDレコード
ord-1236173910b142118fc888e02d448121
出典データセット
uspto-grants-1987_02
特許番号
US04644005

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