Formic Acid → HCID 178469440、化合物
反応式
[NH:1]([C:3](=[NH:18])[C:4]1[CH:5]=[CH:6][C:7]2[N:8]([CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=2)[CH:9]=1)[NH2:2].[CH:19](O)=O>>[NH:2]1[CH:19]=[N:18][C:3]([C:4]2[CH:5]=[CH:6][C:7]3[N:8]([CH:10]=[C:11]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:12]=3)[CH:9]=2)=[N:1]1参加物
3
反応条件
- 温度
- 85 °C
実験手順
A suspension of 580 mg of ethyl 6-[hydrazino(imino)methyl]imidazo[1,2-a]pyridine-2-carboxylate in 6 mL of formic acid is heated for 20 hours at 85° C. The reaction mixture is concentrated to less than 20% of its initial volume and diluted with 20 mL of water. Solid sodium carbonate is added at 0-5° C. to obtain a pH of 8-9. The precipitate is filtered off by suction, and then purified by chromatography on silica, eluting with a mixture of dichloromethane and methanol (98/2) to give 320 mg of ethyl 6-(1H-1,2,4-triazol-3-yl)imidazo[1,2-a]pyridine-2-carboxylate.
後処理
- concentrationThe reaction mixture is concentrated to less than 20% of its initial volume
- addition