Hydrochloric Acid → 3-amino-5-(5-methyl-1H-pyrazol-4-yl)thiophene-2-carboxamide
反応式
CC1(C)[NH:7][C:6]2[CH:8]=[C:9]([C:11]3[CH:12]=[N:13][NH:14][C:15]=3[CH3:16])[S:10][C:5]=2[C:4](=[O:17])[NH:3]1.Cl.C([O-])(O)=O.[Na+]>CO>[NH2:7][C:6]1[CH:8]=[C:9]([C:11]2[CH:12]=[N:13][NH:14][C:15]=2[CH3:16])[S:10][C:5]=1[C:4]([NH2:3])=[O:17]参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of 2,2-dimethyl-6-(5-methyl-1H-pyrazol-4-yl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (660 mg, 2.52 mmol), 1 M HCl (8.81 mL) and MeOH (27 mL) was stirred at 50° C. for 2 h. Then, the reaction mixture was poured into excess saturated aqueous NaHCO3 and extracted with EtOAc/THF, and the extract was dried over MgSO4, filtered and concentrated under reduced pressure to afford the title compound (531 mg, 95%) as a yellow solid.
後処理
- extractionextracted with EtOAc/THF
- dry with materialthe extract was dried over MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-eee1bbba35814653b5606cd8f6cf5f68
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691828B2
反応ノート
読み込み中…