2-Methyl-3-phenyl-1-propanol → Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-

HRID 2364117ノート

反応式

HRID 2364117 の反応式
[CH3:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:3][OH:4]>C1CCCCC1.ClC(Cl)C.[Fe](Cl)Cl>[CH3:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:2]([CH3:5])([CH3:3])[CH3:1])=[CH:8][CH:7]=1)[CH2:3][OH:4]

参加物

5

反応物 1

HCID 956402-Methyl-3-phenyl-1-propanol

生成物 1

HCID 92013Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-収率 84%

試薬・触媒・溶媒 3

HCID 24458Ferrous Chloride触媒HCID 63651,1-Dichloroethane溶媒HCID 8078Cyclohexane溶媒

実験手順

DE 29 52 719 likewise describes the iron chloride-catalyzed Friedel-Crafts alkylation of 2-methyl-3-phenylpropanol. In cyclohexane or dichloroethane solvent, a yield of 84-86% of 2-methyl-3-(4-tert-butylphenyl)propanol was obtained. The formation of the misomeric compound, (2-methyl-3-(3-tert-butylphenyl)propanol), was not demonstrated.

出典と根拠

ORDレコード
ord-4ef1231d16cb40fc981d980f957d618f
出典データセット
uspto-grants-2014_04
特許番号
US08692025B2

反応ノート

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