1-(2-Hydroxyethyl)-2-pyrrolidinone → (2-Oxopyrrolidin-1-yl)acetaldehyde
反応式
[OH:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C1=CC=CC=2)=O>C(Cl)Cl>[O:9]=[C:5]1[CH2:6][CH2:7][CH2:8][N:4]1[CH2:3][CH:2]=[O:1]参加物
4
実験手順
A mixture of N-(2-Hydroxyethyl)-2-pyrrolidone (5.00 g, 38.8 mmol) and triacetoxyperiodinane (24.6 g, 58.0 mmol) in CH2Cl2 was stirred at ambient temperature for approximately 64 hours. The reaction mixture was evaporated in vacuo and the residue was triturated with Et2O. After filtration of the solids, the mother liquor was evaporated in vacuo to provide the product as a crude oil: 1H NMR (CDCl3) δ 9.60 (1H, s), 4.16 (2H, s), 3.46 (2H, t, J=7 Hz), 2.45 (2H, t, J=8 Hz), 2.11 (2H, m).
後処理
- customThe reaction mixture was evaporated in vacuo
- customthe residue was triturated with Et2O
- filtrationAfter filtration of the solids
- customthe mother liquor was evaporated in vacuo
- customto provide the product as a crude oil
出典と根拠
- ORDレコード
- ord-3d0b21a93cc644229f20f714695222a5
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691991B2
反応ノート
読み込み中…