関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1H-1,2,4-Triazole | HCID 9257 | — |
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | 4-Iododibenzofuran | HCID 458257 | — |
| 反応物 | 1-N,2-N-dimethylcyclohexane-1,2-diamine | HCID 551074 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(dibenzo[b,d]furan-4-yl)-1H-1,2,4-triazole | HCID 59859024 | 60% |
反応手順
A mixture of 4-iododibenzo[b,d]furan (5 g, 17.00 mmol), 1H-1,2,4-triazole (3.52 g, 51.0 mmol), CuI (0.162 g, 0.850 mmol), N1,N2-dimethylcyclohexane-1,2-diamine (0.537 mL, 3.40 mmol) and K3PO4 (7.58 g, 35.7 mmol) in DMF (50 mL) was heated at 140° C. for 48 h. After cooling to room temperature, the reaction mixture was filtered through a short plug of Celite®, and the solid was washed with DCM. The combined filtrate was evaporated and purified by column chromatography on silica gel with DCM as eluent to yield 1-(dibenzo[b,d]furan-4-yl)-1H-1,2,4-triazole (2.4 g, 60%) as white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08692241B1 |
|---|
| 出典データセット | uspto-grants-2014_04 |
|---|
| ORD ID | ord-73325ad428cb4a57be647ddc4f96d8a5 |
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| 出典メモ | uspto-grants-2014_04 |
|---|
