Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2364942ノート

反応式

HRID 2364942 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

生成物 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone収率 83%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D2 (2.0 g, 11.96 mmol) in DMF (30 ml). The mixture was stirred overnight at r.t. and was then concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% MeOH/DCM as eluent) to yield intermediate D3 (2.0 g, 83%).

後処理

  1. concentrationwas then concentrated in vacuo
  2. customThe crude product was purified by column chromatography (silica gel; 0-5% MeOH/DCM as eluent)

出典と根拠

ORDレコード
ord-08a2d1aec01d453b9c46bd1e484debd9
出典データセット
uspto-grants-2014_04
特許番号
US08697689B2

反応ノート

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