Water → HCID 178472917、化合物
反応式
[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6](=[O:11])[C:7]([F:10])([F:9])[F:8])[CH3:2].[N:13]([O-])=[O:14].[Na+].O>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:12])[C:5](=[N:13][OH:14])[C:6](=[O:11])[C:7]([F:10])([F:8])[F:9])[CH3:2]参加物
5
実験手順
A stirred solution of 4,4,4-trifluoro-3-oxo-butyric acid ethyl ester (3.822 g, 20.75 mmol) in glacial acetic acid was added dropwise with an aqueous solution of sodium nitrite (4 ml, 20.75 mmol) while maintaining the temperature at 0˜5° C. Upon completion of the addition, 1 ml of water was added. The reaction mixture was stirred in an ice-water bath for 30 minutes and at room temperature for another 3 hours. The solution of 4,4,4-trifluoro-2-hydroxyimino-3-oxo-butyric acid ethyl ester was obtained which was used as such.
後処理
- temperaturewhile maintaining the temperature at 0˜5° C
- additionwas added
出典と根拠
- ORDレコード
- ord-cb54598c6f1946e2a48c64bce312249f
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08697692B2
反応ノート
読み込み中…