Benzoyl Peroxide → HCID 59151288、化合物

HRID 2365162ノート

反応式

HRID 2365162 の反応式
[Br:1][C:2]1[C:3]([CH3:15])=[C:4]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])[CH:5]=[CH:6][CH:7]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:34]Br>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.[W]>[Br:1][C:2]1[C:3]([CH2:15][Br:34])=[C:4]([NH:8][C:9](=[O:14])[C:10]([F:11])([F:13])[F:12])[CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 3

HCID 7187Benzoyl PeroxideHCID 24408BromineHCID 86638092Acetamide, N-(3-bromo-2-methylphenyl)-2,2,2-trifluoro-

生成物 1

HCID 59151288HCID 59151288、化合物

試薬・触媒・溶媒 3

HCID 23964Tungsten触媒HCID 5943Carbon Tetrachloride溶媒2 回HCID 6344Dichloromethane溶媒

実験手順

A solution of N-(3-bromo-2-methyl-phenyl)-2,2,2-trifluoro-acetamide (2.1 g, 7.4 mmol) and benzoyl peroxide (100 mg) in carbon tetrachloride (50 mL) was heated to reflux under irradiation (150 W tungsten lamp). A solution of bromine (0.55 mL, 10.4 mmol) in carbon tetrachloride (3 mL) was then added drop-wise to the refluxing solution, and heating was pursued for 16 h. The reaction mixture was left to cool to RT and diluted with DCM. The organic layer was washed with sodium thiosulfate, and evaporated to dryness to give N-(3-bromo-2-bromomethyl-phenyl)-2,2,2-trifluoro-acetamide as a brown residue which was used without further purification (2.9 g).

後処理

  1. temperatureheating
  2. waitThe reaction mixture was left
  3. washThe organic layer was washed with sodium thiosulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-4339ac566ef44ca793dc15b2971db914
出典データセット
uspto-grants-2014_04
特許番号
US08697693B2

反応ノート

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